|
KMID : 0667720070440000468
|
|
Report Natlonal Institute of Health
2007 Volume.44 No. 0 p.468 ~ p.471
|
|
|
A Multi-Center Collaborative Cohort Study in Rural Communities, Korea
|
|
Choi Bo-Youl
Chun Byung-Yeol
Shin Dong-Hoon
Kweon Sun-Seog
Ahn Youn-Jhin
Kim Sung-Soo
Kwak Hye-Kyoung
Park Man-Seok
Kim Mi-Kyeong
Choi Jin-Su
|
|
|
Abstract
|
|
|
Purpose : Cardiovascular disease (CVD) is estimated to cause approximately a fourth of all deaths in Korea. Ischemic heart disease and cerebral infarction, which are related to atherosclerosis, have been dramatically increasing in recent years. CVD is a typical example of complex disorder, and con sists of diverse diseases which are correlated with each other. Those diseases have various risk factors; each risk factor is related to develop various diseases. A line of studies have reported that cardiovascular disease incorporates with more than 200 risk factors and physiological markers. Risk factors of cardiovascular diseases can be categorized as 1) biological characteristics, such as gender, age, infection, and genetic factor, 2) behavioral factor, including smoking, drinking, dietary pattern, physical activity, and socio-psychological factor, and 3) socio-geographical environment. Those factors could affect physiological marker, such as blood pressure, glucose, lipid, insulin, which causes the intermediate outcome, involving hypertension, diabetes, and atherosclerosis. These will consequently lead to ischemic heart disease or cerebrovascular disease. Pathophysiology of
atherosclerosis is mainly explained by 1) injury of blood vessels, 2) inflammatory reaction, and 3) oxidation response mechanism.
Methods : It developed re-examination, base, and follow-up tool through committee. Developed standard protocol amended after investigation method selection. Research worker and investigator trained the protocol and examination procedure education. It developed the standardization of EKG and IMT interpretations.
Results : For genome epidemiological study in cardiovascular disease, our research teams have developed community-based cohort with 4,300 subjects(2,015 re-examinations and 2,285 bases) in rural areas, including Gyeonggi-do, Gyeongsangbuk-do, and Jeollabuk-do.
Conclusions : This cohort study should 1) involve accurate laboratory tests to characterize various diseases of CVD in detail, 2) standardize and upgrade the quality of surveys, 3) maintain the good quality in the subsequent repeated survey, and, 4) ensure the high participation rate of target population in re-examination surveys.Multi-Center, Rural, community-based Cohort
|
|
|
KEYWORD
|
|
|
Multi-Center, Rural, community-based Cohort
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|